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Christophe Phillips - Publications ORBI
Desseilles, M., & Phillips, C. (2017). How cognition affects perception: Brain activity modelling to unravel top-down dynamics. Behavioral and Brain Sciences, 39.
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In this commentary on Firestone & Scholl's (F&S's) article, we argue that researchers should use brain-activity modelling to investigate top-down mechanisms. Using functional brain imaging and a specific ...
Manard, M., François, S., Phillips, C., SALMON, E., & Collette, F. (2017). The neural bases of proactive and reactive control processes in normal aging. Behavioural Brain Research, 320, 504-516.
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Introduction. Research on cognitive control suggests an age-related decline in proactive control abilities (anticipatory control), whereas reactive control (following conflict detection) seems to remain intact ...
Schrouff, J., Mourao-Miranda, J., Phillips, C., & Parvizi, J. (2016). Decoding intracranial EEG data with multiple kernel learning method. Journal of Neuroscience Methods, 261, 19-28.
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Machine learning models have been successfully applied to neuroimaging data to make predictions about behavioral and cognitive states of interest. While these multivariate methods have greatly advanced the ...
Coppieters't Wallant, D., Muto, V., Gaggioni, G., Jaspar, M., Chellappa, S. L., Meyer, C., Vandewalle, G., Maquet, P., & Phillips, C. (2016). Automatic artifacts and arousals detection in whole-night sleep EEG recordings. Journal of Neuroscience Methods, 258.
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In sleep electroencephalographic (EEG) signals, artifacts and arousals marking are usually part of the processing. This visual inspection by a human expert has two main drawbacks: it is very time consuming and ...
Majerus, S., Cowan, N., Peters, F., Van Calster, L., Phillips, C., & Schrouff, J. (2016). Cross-Modal Decoding of Neural Patterns Associated with Working Memory: Evidence for Attention-Based Accounts of Working Memory. Cerebral Cortex, 26, 166-179.
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Recent studies suggest common neural substrates involved in verbal and visual working memory (WM), interpreted as reflecting shared attention-based, short-term retention mechanisms. We used a machine-learning ...
Segovia, F., Górriz, J. M., Ramírez, J., Phillips, C., & Alzheimer’s Disease Neuroimaging Initiative. (2016). Combining feature extraction methods to assist the diagnosis of Alzheimer's disease. Current Alzheimer Research, 13.
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Neuroimaging data as 18F-FDG PET is widely used to assist the diagnosis of Alzheimer’s disease (AD). Looking for regions with hypoperfusion/ hypometabolism, clinicians may predict or corroborate the diagnosis ...
Vanvinckenroye, A., Vandewalle, G., Phillips, C., & Chellappa, S. L. (2015, October). Eyes Open on Sleep and Wake: In Vivo to In Silico Neural Networks. Neural Plasticity.
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Functional and effective connectivity of cortical areas are essential for normal brain function under different behavioral states. Appropriate cortical activity during sleep and wakefulness is ensured by the ...
Bretin, F., Bahri, M. A., Luxen, A., Phillips, C., Plenevaux, A., & Seret, A. (2015). Monte Carlo simulations of the dose from imaging with GE eXplore 120 micro-CT using gate. Medical Physics, 42(10), 5711-5719.
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Purpose: Small animals are increasingly used as translational models in preclinical imaging studies, during which the subjects can be exposed to large amounts of radiation. While the radiation levels are ...
Liegeois, R., Ziegler, E., Bahri, M. A., Phillips, C., Geurts, P., Gomez, F., Yeo, T., VANHAUDENHUYSE, A., Soddu, A., LAUREYS, S., & Sepulchre, R. (2015, July). Cerebral functional connectivity periodically (de)synchronizes with anatomical constraints. Brain Structure and Function.
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This paper studies the link between resting-state functional connectivity (FC), measured by the correlations of the fMRI BOLD time courses, and structural connectivity (SC), estimated through fiber ...
Liegeois, R., Phillips, C., Bahri, M. A., LAUREYS, S., & Sepulchre, R. (2015). Total connectivity: a marker of dynamical functional connectivity applied to consciousness. Poster session presented at Organization for Human Brain Mapping, USA.
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In the last years functional connectivity (FC) has become one of the most popular tools to explore and characterize information contained in fMRI =me series. The classical hypothesis on FC consists of ...
Maire, M., Reichert, C. F., Gabel, V., Viola, A. U., Phillips, C., Krebs, J., Scheffler, K., Klarhofer, M., Strobel, W., Cajochen, C., & Schmidt, C. (2015). Fighting Sleep at Night: Brain Correlates and Vulnerability to Sleep Loss. Annals of neurology, 78(2), 235-47.
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OBJECTIVE: Even though wakefulness at night leads to profound performance deterioration and is regularly experienced by shift workers, its cerebral correlates remain virtually unexplored. METHODS: We assessed ...
Ziegler, E., Chellappa, S. L., Gaggioni, G., Ly, J., Vandewalle, G., André, E., Geuzaine, C.* , & Phillips, C.* . (2014). A finite-element reciprocity solution for EEG forward modeling with realistic individual head models. NeuroImage, 103, 542-551.
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Highlights • Creates EEG forward models suitable for high-resolution source localization. • Automatic T1-based whole-head finite element meshing and leadfield computation. • Pipelines can incorporate ...
* These authors have contributed equally to this work.
Ziegler, E., Rouillard, M., André, E., Coolen, T., Stender, J., Balteau, E., Phillips, C.* , & Garraux, G.* . (2014). Mapping track density changes in nigrostriatal and extranigral pathways in Parkinson's disease. NeuroImage, 99, 498-508.
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Highlights First whole-brain probabilistic tractography study in Parkinson's disease High quality diffusion-weighted images (120 gradient directions, b = 2500 s/mm2) Voxel-based group analysis comparing early ...
* These authors have contributed equally to this work.
Schrouff, J., Foster, B. L., Rangarajan, V., Phillips, C., Mourao-Miranda, J., & Parvizi, J. (2014). Decoding memory processing from electro-corticography in human posteromedial cortex. International Workshop on Pattern Recognition in Neuroimaging.
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Recently machine learning models have been applied to neuroimaging data, which allow predictions about a variable of interest based on the pattern of activation or anatomy over a set of voxels. These pattern ...
Segovia-Román, F., Holt, R., Spencer, M., Górriz Sáez, J. M., Ramírez Pérez de Inestrosa, J., Puntonet, C. G., Phillips, C., Chura, L., Baron-Cohen, S., & Suckling, J. (2014). Identifying endophenotypes of autism: a multivariate approach. Frontiers in Computational Neuroscience, 8.
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The existence of an endophenotype of autism spectrum condition (ASC) has been recently suggested by several commentators. It can be estimated by finding differences between controls and people with ASC that ...
André, E., Grinberg, F., Farrher, E., Maximov, I. I., Shah, N. J., Meyer, C., Jaspar, M., Muto, V., Phillips, C., & Balteau, E. (2014, April). Influence of noise correction on intra- and inter-subject variability of quantitative metrics in diffusion kurtosis imaging. PLoS ONE.
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Diffusion kurtosis imaging (DKI) is a promising extension of diffusion tensor imaging, giving new insights into the white matter microstructure and providing new biomarkers. Given the rapidly increasing number ...
Noirhomme, Q., Lesenfants, D., Gomez, F., Soddu, A., Schrouff, J., Garraux, G., Luxen, A., Phillips, C.* , & Laureys, S.* . (2014). Biased binomial assessment of cross-validated estimation of classification accuracies illustrated in diagnosis predictions. NeuroImage: Clinical, 4, 687-694.
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Multivariate classification is used in neuroimaging studies to infer brain activation or in medical applications to infer diagnosis. Their results are often assessed through either a binomial or a permutation ...
* These authors have contributed equally to this work.
Segovia-Román, F., Bastin, C., Salmon, E., Górriz Sáez, J. M., Ramírez Pérez de Inestrosa, J., & Phillips, C. (2014). Combining PET images and neuropsychological test data for automatic diagnosis of Alzheimer’s disease. PLoS ONE, 9(2).
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In recent years, several approaches to develop computer aided diagnosis (CAD) systems for dementia have been proposed. Some of these systems analyze neurological brain images by means of machine learning ...
D'Argembeau, A., Cassol, H., Phillips, C., Balteau, E., Salmon, E., & Van der Linden, M. (2014). Brains creating stories of selves: the neural basis of autobiographical reasoning. Social Cognitive and Affective Neuroscience, 9, 646-652.
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Personal identity critically depends on the creation of stories about the self and one's life. The present study investigates the neural substrates of autobiographical reasoning, a process central to the ...
Liegeois, R., Ziegler, E., Phillips, C., Gomez, F., Soddu, A., LAUREYS, S., & Sepulchre, R. (2014). Assessing dynamical correlations between functional and structural brain connectivity. Poster session presented at 20th Conference of the Organization for Human Brain Mapping, Hamburg, Germany.
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The link between resting­‐state functional connectivity (FC), measured by the correlations of the fMRI BOLD time courses, and structural connectivity (SC) has been repeatedly investigated recently. Meanwhile ...
Segovia-Román, F., & Phillips, C. (2014). PET imaging analysis using a parcelation approach and multiple kernel classification. International Workshop on Pattern Recognition in Neuroimaging, Tübingen 4-6 June 2014.
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Positron Emission Tomography (PET) is a non-invasive medical imaging modality that provides information about physiological processes. Due to its ability to measure the brain metabolism, it is widely used to ...
Sterpenich, V., Schmidt, C., Albouy, G., Matarazzo, L., VANHAUDENHUYSE, A., BOVEROUX, P., Degueldre, C., Leclercq, Y., Balteau, E., Collette, F., Luxen, A., Phillips, C., & Maquet, P. (2014). Memory reactivation during rapid eye movement sleep promotes its generalization and integration in cortical stores. Sleep, 37(6), 1061-75, 1075A-1075.
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STUDY OBJECTIVES: Memory reactivation appears to be a fundamental process in memory consolidation. In this study we tested the influence of memory reactivation during rapid eye movement (REM) sleep on memory ...
Noirhomme, Q., Lesenfants, D., Gomez, F., Soddu, A., Luxen, A., Phillips, C., & Laureys, S. (2013, December). On the statistical assessment of small sample classification. Paper presented at Annual symposium of the IEEE EMBS & IM Benelux chapter, Brussels, Belgium.
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Classifiers start to be used in medical application to infer diagnosis. Their results are assessed through either a binomial or a permutation test. Distributions built from classification of random data ...
Gomez Jaramillo, F. A.* , Phillips, C.* , Soddu, A., Boly, M., BOVEROUX, P., Vanhaudenhuyse, A., Bruno, M.-A., Gosseries, O., BONHOMME, V., Laureys, S., & Noirhomme, Q. (2013). Changes in Effective Connectivity by Propofol Sedation. PLoS ONE, 8(8), 71370.
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Mechanisms of propofol-induced loss of consciousness remain poorly understood. Recent fMRI studies have shown decreases in functional connectivity during unconsciousness induced by this anesthetic agent ...
* These authors have contributed equally to this work.
Ziegler, E., Foret, A., Mascetti, L., Muto, V., Le Bourdiec-Shaffii, A., Stender, J., Balteau, E., DIDEBERG, V., Bours, V., Maquet, P., & Phillips, C. (2013, August). Altered white matter architecture in BDNF Met carriers. PLoS ONE.
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Brain-derived neurotrophic factor (BDNF) modulates the pruning of synaptically-silent axonal arbors. The Met allele of the BDNF gene is associated with a reduction in the neurotrophin's activity-dependent ...
Schrouff, J., Rosa, M., Rondina, J., Marquand, A., Chu, C., Ashburner, J., Phillips, C., Richiardi, J., & Mourão-Miranda, J. (2013, June). Multivariate pattern interpretation using PRoNTo. Poster session presented at Organization of Human Brain Mapping, Seattle, USA.
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Recently, machine learning models have been applied to neuroimaging data, allowing to make predictions about a variable of interest based on the pattern of activation or anatomy over a set of voxels. In ...
Schrouff, J., Rosa, M. J., Rondina, J., Marquand, A., Chu, C., Ashburner, J., Phillips, C., Richiardi, J., & Mourão-Miranda, J. (2013). PRoNTo: Pattern Recognition for Neuroimaging Toolbox. Neuroinformatics, 11(3), 319-337.
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In the past years, mass univariate statistical analyses of neuroimaging data have been complemented by the use of multivariate pattern analyses, especially based on machine learning models. While these allow ...
Angel, L., Bastin, C., Genon, S., Balteau, E., Phillips, C., Luxen, A., Maquet, P., Salmon, E., & Collette, F. (2013). Differential effects of aging on the neural correlates of recollection and familiarity. Cortex : A Journal Devoted to the Study of the Nervous System & Behavior, 49, 1585-1597.
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The present experiment aimed to investigate age differences in the neural correlates of familiarity and recollection, while keeping performance similar across age groups by varying task difficulty. Twenty ...
Dardenne, B., Dumont, M., Sarlet, M., Phillips, C., Balteau, E., Luxen, A., Salmon, E., Maquet, P., & Collette, F. (2013). Benevolent sexism alters executive brain responses. Neuroreport, 24(10), 572-577.
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Benevolence is widespread in our societies. It is defined as considering a subordinate group nicely but condescendingly, that is, with charity. Deleterious consequences for the target have been reported in the ...
Garraux, G.* , Phillips, C.* , Schrouff, J., Kreisler, A., Lemaire, C., Degueldre, C., Delcour, C., Hustinx, R., Luxen, A., Destée, A., & Salmon, E. (2013). Multiclass classification of FDG PET scans for the distinction between Parkinson's disease and atypical parkinsonian syndromes. NeuroImage: Clinical, 2, 883-893.
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Most available pattern recognition methods in neuroimaging address binary classification problems. Here, we used relevance vector machine (RVM) in combination with booststrap resampling (‘bagging’) for non ...
* These authors have contributed equally to this work.
Grandjean, J., D'Ostilio, K., Fias, W., Phillips, C., Balteau, E., Degueldre, C., Luxen, A., Maquet, P., Salmon, E., & Collette, F. (2013). Exploration of the mechanisms underlying the ISPC effect: Evidence from behavioral and neuroimaging data. Neuropsychologia, 51, 1040-1049.
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The item-specific proportion congruent (ISPC) effect in a Stroop task – the observation of reduced interference for color words mostly presented in an incongruent color – has attracted growing interest since ...
Mascetti, L., Foret, A., Schrouff, J., Muto, V., DIDEBERG, V., Balteau, E., Degueldre, C., Phillips, C., Luxen, A., Collette, F., BOURS, V., & MAQUET, P. (2013). Concurrent Synaptic and Systems Memory Consolidation during Sleep. Journal of Neuroscience, 33(24), 10182-10190.
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Memories are consolidated during sleep by two apparently antagonistic processes: (1) reinforcement of memory-specific cortical interactions and (2) homeostatic reduction in synaptic efficiency. Using fMRI, we ...
Segovia-Román, F., Bastin, C., Salmon, E., Górriz, J. M., Ramírez, J., & Phillips, C. (2013). Automatic differentiation between Alzheimer’s Disease and Mild Cognitive Impairment combining PET data and psychological scores. 3rd International Workshop on Pattern Recognition in Neuroimaging (pp. 144-147).
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In recent years, several approaches to develop computer aided diagnosis systems for dementia have been pro- posed. The purpose of this work is to measure the advantages of using not only brain images as data ...
Segovia-Román, F., Bastin, C., Salmon, E., & Phillips, C. (2013). Classification of MCI and AD patients combining PET data and psychological scores. International Workshop on Advances in Regularization, Optimization, Kernel Methods and Support Vector Machines: theory and applications (pp. 97-98).
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This study’s aim was to measure the advantages of using psychological test data in the automatic classification of functional brain images in order to assist the diagnosis of neurodegenerative disorders such ...
Segovia-Román, F., Bastin, C., Salmon, E., & Phillips, C. (2013). Classification of positron emission tomography images using multiple kernel learning. Proceeding of 3rd NIPS 2013 Workshop on Machine Learning and Interpretation in NeuroImaging (pp. 1-7).
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Over the last years, several approaches to analyze nuclear medicine imaging using computer systems have been proposed with the aim of assisting the diagnosis of neurodegenerative disorders. Probably one of the ...
Schrouff, J., Cremers, J., D'Ostilio, K., Delvaux, V., Garraux, G., & Phillips, C. (2012, December 07). Discriminant BOLD Activation Patterns during Mental Imagery in Parkinson’s Disease. Proceedings of MLINI 2012.
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Using machine learning based models in clinical applications has become current practice and can prove useful to provide information at the subject’s level, such as predicting an (early) diagnosis or ...
Bretin, F., Warnock, G., Bahri, M. A., Libert, L., Lemaire, C., Phillips, C., Plenevaux, A., Luxen, A., & Seret, A. (2012, October). Dosimetry for 6-[18F]Fluoro-L-DOPA in Humans Based on Biodistribution in Mice. Poster session presented at EANM'12 Annual Congress of the European Association of Nuclear Medicine, Milano, Italy.
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Aim. The objective of this work was to estimate human dosimetry for 6-[18F]Fluoro-L-DOPA (F-DOPA) from biodistribution in mice, obtained from organ harvesting at different time points and from a hybrid method ...
D'Ostilio, K., Collette, F., Phillips, C., & Garraux, G. (2012, October). Evidence for a role of a cortico-subcortical network for automatic and unconscious motor inhibition of manual responses. PLoS ONE.
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It is now clear that non-consciously perceived stimuli can bias our decisions. Although previous researches highlighted the importance of automatic and unconscious processes involved in voluntary action, the ...
Bretin, F., Warnock, G., Bahri, M. A., Libert, L., Lemaire, C., Phillips, C., Seret, A., Luxen, A., & Plenevaux, A. (2012, September). Dosimetry for 6-[18F]Fluoro-L-DOPA in humans based on in vivo microPET scans and ex vivo tissue distribution in mice. Poster session presented at World Molecular Imaging Congress, Dublin, Ireland.
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Radiation dosimetry of new radiopharmaceuticals generally starts with studies in small animals such as mice and rats. The traditional technique has long been ex vivo measurement of the biodistribution over ...
Genon, S., Collette, F., Feyers, D., Phillips, C., Salmon, E., & Bastin, C. (2012). Item familiarity and controlled associative retrieval in Alzheimer’s disease: an fMRI study. Proceedings of the Amsterdam Memory Slam 2012 (pp. 16).
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Alzheimer’s disease (AD) is characterised by altered recollection function, with impaired controlled retrieval of associations. In contrast, familiarity-based memory for individual items may sometimes be ...
Phillips, C., Schrouff, J., Luxen, A., Salmon, E., & Garraux, G. (2012, June 10). Automatic multiclass classification of 18FDG-PET scans for the distinction between Parkinson’s disease and atypical parkinsonian syndromes. Poster session presented at Organization of Human Brain Mapping, Beijing, China.
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Part of the difficulty in the early diagnosis of Parkinson’s disease (PD) is in differentiating it from atypical parkinsonian disorders (APS) that have a poorer prognosis such as multiple system atrophy (MSA ...
D'Argembeau, A., Jedidi, H., Balteau, E., Bahri, M. A., Phillips, C., & Salmon, E. (2012). Valuing One's Self: Medial Prefrontal Involvement in Epistemic and Emotive Investments in Self-views. Cerebral Cortex, 22, 659-667.
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Recent neuroimaging research has revealed that the medial prefrontal cortex (MPFC) is consistently engaged when people form mental representations of themselves. However, the precise function of this region in ...
Genon, S., Collette, F., Feyers, D., Phillips, C., SALMON, E., & Bastin, C. (2012). Item familiarity and controlled associative retrieval in Alzheimer’s disease: An fMRI study. Frontiers in Human Neuroscience.
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Alzheimer’s disease (AD) is characterised by altered recollection function, with impaired controlled retrieval of associations. In contrast, familiarity-based memory for individual items may sometimes be ...
Grandjean, J., D'Ostilio, K., Phillips, C., Balteau, E., Degueldre, C., Luxen, A., Maquet, P., Salmon, E., & Collette, F. (2012). Modulation of brain activity during a Stroop inhibitory task by the kind of cognitive control required. PLoS ONE, 7(7), 41513.
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This study used a proportion congruency manipulation in the Stroop task in order to investigate, at the behavioral and brain substrate levels, the predictions derived from the Dual Mechanisms of Control (DMC ...
Majerus, S., Attout, L., D'Argembeau, A., Degueldre, C., Fias, W., Maquet, P., Martinez Perez, T., Stawarczyk, D., Salmon, E., Van der Linden, M., Phillips, C., & Balteau, E. (2012). Attention Supports Verbal Short-Term Memory via Competition between Dorsal and Ventral Attention Networks. Cerebral Cortex, 22, 1086-1097.
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Interactions between the neural correlates of short-term memory (STM) and attention have been actively studied in the visual STM domain but much less in the verbal STM domain. Here we show that the same ...
Schrouff, J., Kussé, C., Wehenkel, L., Maquet, P., & Phillips, C. (2012). Decoding Semi-Constrained Brain Activity from fMRI Using Support Vector Machines and Gaussian Processes. PLoS ONE, 7(4).
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Predicting a particular cognitive state from a specific pattern of fMRI voxel values is still a methodological challenge. Decoding brain activity is usually performed in highly controlled experimental ...
Schrouff, J., & Phillips, C. (2012). Multivariate pattern analysis: brain decoding. In C., Schnakers & S., Laureys (Eds.), Coma and altered states of consciousness (pp. 41-48). London, UK: Springer.
Two of the most fundamental questions in the field of neurosciences are how information is represented in different brain structures, and how this information evolves over time. Various tools, such as Magnetic ...
Schrouff, J., Rosa, M. J., Rondina, J., Marquand, A., Chu, C., Ashburner, J., Phillips, C., Richiardi, J., & Mourao-Miranda, J. (2012). PRoNTo: Pattern Recognition for Neuroimaging Toolbox.
PRoNTo (Pattern Recognition for Neuroimaging Toolbox) is a software toolbox based on pattern recognition techniques for the analysis of neuroimaging data. Statistical pattern recognition is a field within the ...
Schrouff, J., Kussé, C., Wehenkel, L., Maquet, P., & Phillips, C. (2011, November 22). Decoding semi-constrained brain activity from fMRI using SVM and GP. Paper presented at I Workshop on Mathematical Modeling and Computational Neuroscience of UFABC, São Paulo, Brazil.
Predicting a particular cognitive state from a specific pattern of fMRI voxel values is still a methodological challenge. Decoding brain activity is usually performed in highly controlled experimental ...
Demertzi, A., Soddu, A., FAYMONVILLE, M.-E., Bahri, M. A., Gosseries, O., Vanhaudenhuyse, A., Phillips, C., Maquet, P., Luxen, A., & Laureys, S. (2011). Hypnotic modulation of resting state fMRI default mode and extrinsic network connectivity. Progress in Brain Research, 193, 309-322.
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Resting state fMRI (functional magnetic resonance imaging) acquisitions are characterized by low-frequency spontaneous activity in a default mode network (encompassing medial brain areas and linked to self ...
Schrouff, J., Leclercq, Y., Noirhomme, Q., Maquet, P., & Phillips, C. (2011, June 28). FASST- a FMRI Artefact rejection and Sleep Scoring Toolbox. Poster session presented at Organization of Human Brain Mapping, Québec, Canada.
Peer reviewed
We started writing the “fMRI artefact rejection and sleep scoring toolbox”, or “FASST”, to process our sleep EEG-fMRI data, that is, the simultaneous recording of electroencephalographic and functional ...
Schrouff, J., Kussé, C., Wehenkel, L., Maquet, P., & Phillips, C. (2011, June 26). Decoding Directed Brain Activity in fMRI using Support Vector Machines and Gaussian Processes. Poster session presented at Organization of Human Brain Mapping, Québec, Canada.
Peer reviewed
Predicting a particular cognitive state from a specific pattern of fMRI voxel values is still a methodological challenge. Decoding brain activity is usually performed in highly controlled experimental ...
Desseilles, M., Schwartz, S., Dang Vu, T. T., Sterpenich, V., Ansseau, M., Maquet, P., & Phillips, C. (2011). Depression alters "top-down" visual attention: a dynamic causal modeling comparison between depressed and healthy subjects. NeuroImage, 54(2), 1662-8.
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Using functional magnetic resonance imaging (fMRI), we recently demonstrated that nonmedicated patients with a first episode of unipolar major depression (MDD) compared to matched controls exhibited an ...
Leclercq, Y., Schrouff, J., Noirhomme, Q., Maquet, P., & Phillips, C. (2011). fMRI Artefact Rejection and Sleep Scoring Toolbox. Computational Intelligence & Neuroscience.
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This paper proposes a toolbox for handling large EEG/ MEG data sets, rejecting the artefact linked to joint fMRI-EEG acquisitions and scoring data sets.
Litvak, V., Mattout, J., Kiebel, S., Phillips, C., Henson, R., Kilner, J., Barnes, G., Oostenveld, R., Daunizeau, J., Flandin, G., Penny, W., & Friston, K. (2011). EEG andMEG Data Analysis in SPM8. Computational Intelligence and Neuroscience, 2011(ID 852961), 32.
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SPMis a free and open source software written inMATLAB (The MathWorks, Inc.). In addition to standardM/EEG preprocessing, we presently offer three main analysis tools: (i) statistical analysis of scalp-maps ...
Murphy, M., Bruno, M.-A., Riedner, B. A., BOVEROUX, P., Noirhomme, Q., Landsness, E. C., BRICHANT, J.-F., Phillips, C., Massimini, M., Laureys, S., Tononi, G., & Boly, M. (2011). Propofol anesthesia and sleep: a high-density EEG study. Sleep, 34(3), 283-91.
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STUDY OBJECTIVES: The electrophysiological correlates of anesthetic sedation remain poorly understood. We used high-density electroencephalography (hd-EEG) and source modeling to investigate the cortical ...
Phillips, C., Bruno, M.-A., Maquet, P., Boly, M., Noirhomme, Q., Schnakers, C., Vanhaudenhuyse, A., Bonjean, M., Hustinx, R., Moonen, G., Luxen, A., & Laureys, S. (2011). "Relevance vector machine" consciousness classifier applied to cerebral metabolism of vegetative and locked-in patients. NeuroImage, 56(2), 797–808.
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The vegetative state is a devastating condition where patients awaken from their coma (i.e., open their eyes) but fail to show any behavioural sign of conscious awareness. Locked-in syndrome patients also ...
Schrouff, J., Perlbarg, V., Boly, M., Marrelec, G., BOVEROUX, P., Vanhaudenhuyse, A., Bruno, M.-A., Laureys, S., Phillips, C., Pélégrini-Issac, M., Maquet, P., & Benali, H. (2011). Brain functional integration decreases during propofol-induced loss of consciousness. NeuroImage, 57(1), 198-205.
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Consciousness has been related to the amount of integrated information that the brain is able to generate. In this paper, we tested the hypothesis that the loss of consciousness caused by propofol anesthesia ...
Vanhaudenhuyse, A.* , Demertzi, A.* , Schabus, M., Noirhomme, Q., Brédart, S., Boly, M., Phillips, C., Soddu, A., Luxen, A., MOONEN, G., & Laureys, S. (2011). Two distinct neuronal networks mediate the awareness of environment and of self. Journal of Cognitive Neuroscience, 23(3), 570-578.
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Evidence from functional neuroimaging studies on resting state suggests that there are two distinct anticorrelated cortical systems that mediate conscious awareness: an "extrinsic" system that encompasses ...
* These authors have contributed equally to this work.
Schmidt, C., Peigneux, P., Maquet, P., & Phillips, C. (2010, April). Response to Comment on “Homeostatic Sleep Pressure and Responses to Sustained Attention in the Suprachiasmatic Area”. Science.
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Astafiev et al. question whether the blood oxygen level–dependent (BOLD) response that we reported in the brainstem was located in the locus coeruleus (LC). Using high-resolution T1-turbo spin echo images ...
Vandewalle, G., Schwartz, S., Grandjean, D., Wuillaume, C., Balteau, E., Degueldre, C., Schabus, M., Phillips, C., Luxen, A., Dijk, D. J., & Maquet, P. (2010). Spectral quality of light modulates emotional brain responses in humans. Proceedings of the National Academy of Sciences of the United States of America, 107(45), 19549-54.
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Light therapy can be an effective treatment for mood disorders, suggesting that light is able to affect mood state in the long term. As a first step to understand this effect, we hypothesized that light might ...
Schrouff, J., Leclercq, Y., Foret, A., Mascetti, L., Maquet, P., & Phillips, C. (2009, December 14). Characterization of spatio-temporal organization of slow waves during human NREM sleep. Poster session presented at Benelux Bioinformatics Conference, Liège, Belgium.
Peer reviewed
Sleep is a behavior commonly observed in a large number of animal species. However, neuroscientists still poorly understand the meaning of this loss of consciousness absolutely needed for life. In the present ...
Sterpenich, V., Albouy, G., Darsaud, A., Schmidt, C., Vandewalle, G., Dang Vu, T. T., Desseilles, M., Phillips, C., Degueldre, C., Balteau, E., Collette, F., Luxen, A., & Maquet, P. (2009). Sleep promotes the neural reorganization of remote emotional memory. Journal of Neuroscience, 29(16), 5143-52.
Peer reviewed (verified by ORBi)
Sleep promotes memory consolidation, a process by which fresh and labile memories are reorganized into stable memories. Emotional memories are usually better remembered than neutral ones, even at long ...
Henson, R. N., Mattout, J., Phillips, C., & Friston, K. J. (2009). Selecting forward models for MEG source-reconstruction using model-evidence. NeuroImage, 46(1), 168-76.
Peer reviewed (verified by ORBi)
We investigated four key aspects of forward models for distributed solutions to the MEG inverse problem: 1) the nature of the cortical mesh constraining sources (derived from an individual's MRI, or inverse ...
Leclercq, Y., Balteau, E., Dang Vu, T. T., Schabus, M., Luxen, A., Maquet, P., & Phillips, C. (2009). Rejection of pulse related artefact (PRA) from continuous electroencephalographic (EEG) time series recorded during functional magnetic resonance imaging (fMRI) using constraint independent component analysis (cICA). NeuroImage, 44(3), 679-91.
Peer reviewed (verified by ORBi)
Rejection of the pulse related artefact (PRA) from electroencephalographic (EEG) time series recorded simultaneously with fMRI data is difficult, particularly during NREM sleep because of the similarities ...
Noirhomme, Q., Boly, M., Bonhomme, V., Boveroux, P., Phillips, C., Peigneux, P., Soddu, A., Luxen, A., Moonen, G., Maquet, P., & Laureys, S. (2009). Bispectral index correlates with regional cerebral blood flow during sleep in distinct cortical and subcortical structures in humans. Archives Italiennes de Biologie, 147(1-2), 51-7.
Peer reviewed (verified by ORBi)
The relationship between the Bispectral Index (BIS), an EEG-based monitor of anesthesia, and brain activity is still unclear. This study aimed at investigating the relationship between changes in BIS values ...
Aerts, J., Plenevaux, A., Lemaire, C., Giacomelli, F., Warnock, G., Phillips, C., & Luxen, A. (2008). Metabolism of no-carrier-added 2-[18F]fluoro-L-tyrosine in rats. BMC Medical Physics, 8, 4.
Peer reviewed (verified by ORBi)
Background: Several fluorine-18 labelled fluoroamino acids have been evaluated as tracers for the quantitative assessment of cerebral protein synthesis in vivo by positron emission tomography (PET). Among ...
Bonhomme, V., Maquet, P., Phillips, C., Plenevaux, A., Hans, P., Luxen, A., Lamy, M., & Laureys, S. (2008). The Effect of Clonidine Infusion on Distribution of Regional Cerebral Blood Flow in Volunteers. Anesthesia and Analgesia, 106(3), 899-909.
Peer reviewed (verified by ORBi)
BACKGROUND: Through their action on the locus coeruleus, alpha2-adrenoceptor agonists induce rapidly reversible sedation while partially preserving cognitive brain functions. Our goal in this observational ...
Kiebel, S. J., Daunizeau, J., Phillips, C., & Friston, K. J. (2008). Variational Bayesian inversion of the equivalent current dipole model in EEG/MEG. Neuroimage, 39(2), 728-741.
Peer reviewed (verified by ORBi)
In magneto- and electroencephalography (M/EEG), spatial modelling of sensor data is necessary to make inferences about underlying brain activity. Most source reconstruction techniques belong to one of two ...
Boly, M., Faymonville, M.-E., Schnakers, C., Peigneux, P., Lambermont, B., Phillips, C., Lancellotti, P., Luxen, A., Lamy, M., Moonen, G., Maquet, P., & Laureys, S. (2008). Perception of pain in the minimally conscious state with PET activation: an observational study. Lancet Neurology, 7(11), 1013-20.
Peer reviewed (verified by ORBi)
BACKGROUND: Patients in a minimally conscious state (MCS) show restricted self or environment awareness but are unable to communicate consistently and reliably. Therefore, better understanding of cerebral ...
Boly, M., Phillips, C., Balteau, E., Schnakers, C., Degueldre, C., Moonen, G., Luxen, A., Peigneux, P., Faymonville, M., Maquet, P., & Laureys, S. (2008). Consciousness and cerebral baseline activity fluctuations. Human Brain Mapping, 29, 868-874.
Peer reviewed (verified by ORBi)
The origin of within-subject variability in perceptual experiments is poorly understood. We here review evidence that baseline brain activity in the areas involved in sensory perception predict subsequent ...
Boly, M., Phillips, C., Tshibanda, L., Vanhaudenhuyse, A., Schabus, M., Dang Vu, T. T., Moonen, G., Hustinx, R., Maquet, P., & Laureys, S. (2008). Intrinsic brain activity in altered states of consciousness: how conscious is the default mode of brain function? Annals of the New York Academy of Sciences, 1129, 119-29.
Peer reviewed (verified by ORBi)
Spontaneous brain activity has recently received increasing interest in the neuroimaging community. However, the value of resting-state studies to a better understanding of brain-behavior relationships has ...
Friston, K., Harrison, L., Daunizeau, J., Kiebel, S., Phillips, C., Trujillo-Barreto, N., Henson, R., Flandin, G., & Mattout, J. (2008). Multiple sparse priors for the M/EEG inverse problem. NeuroImage, 39(3), 1104-20.
Peer reviewed (verified by ORBi)
This paper describes an application of hierarchical or empirical Bayes to the distributed source reconstruction problem in electro- and magnetoencephalography (EEG and MEG). The key contribution is the ...
Salmon, E., D'Argembeau, A., Bastin, C., Feyers, D., Phillips, C., Laureys, S., Maquet, P., & Collette, F. (2008). Imagerie cérébrale de la réflexion sur soi. Revue Médicale de Liège, 63, 458-460.
Peer reviewed (verified by ORBi)
Precise brain regions are activated when a subject gives a judgment on himself. Those are the medial parietal cortex, essentially related to episodic memory processing, and the ventromedial prefrontal cortex ...
Boly, M., Balteau, E., Schnakers, C., Degueldre, C., Moonen, G., Luxen, A., Phillips, C., Peigneux, P., Maquet, P., & Laureys, S. (2007). Baseline brain activity fluctuations predict somatosensory perception in humans. Proceedings of the National Academy of Sciences of the United States of America, 104(29), 12187-12192.
Peer reviewed (verified by ORBi)
In perceptual experiments, within-individual fluctuations in perception are observed across multiple presentations of the same stimuli, a phenomenon that remains only partially understood. Here, by means of ...
Mattout, J., Phillips, C., Daunizeau, J., & Friston, K. (2007). Bayesian inversion for induced responses. In K., Friston, J., Ashburner, S., Kiebel, T., Nichols, & W., Penny (Eds.), Statistical Parametric Mapping: the analysis of functional brain images. Academic Press.
The book Statistical Parametric Mapping: The Analysis of Functional Brain Images (2007) provides the background and methodology for the analysis of all types of brain imaging data, from functional magnetic ...
Mattout, J., Phillips, C., Daunizeau, J., & Friston, K. (2007). Bayesian inversion of EEG models. In K., Friston, J., Ashburner, S., Kiebel, T., Nichols, & W., Penny (Eds.), Statistical Parametric Mapping: the analysis of functional brain images. Academic Press.
The book Statistical Parametric Mapping: The Analysis of Functional Brain Images (2007) provides the background and methodology for the analysis of all types of brain imaging data, from functional magnetic ...
Phillips, C., Mattout, J., & Friston, K. (2007). Forward models for EEG. In K., Friston, J., Ashburner, S., Kiebel, T., Nichols, & W., Penny (Eds.), Statistical Parametric Mapping: the analysis of functional brain images. Academic Press.
The book Statistical Parametric Mapping: The Analysis of Functional Brain Images (2007) provides the background and methodology for the analysis of all types of brain imaging data, from functional magnetic ...
Phillips, C., Schrouff, J., Coppieters't Wallant, D., Degueldre, C., Lehembre, R., Leclercq, Y., & Maquet, P. (2007). FASST - fMRI Artefact rejection and Sleep Scoring Toolbox.
"FASST" stands for "fMRI Artefact rejection and Sleep Scoring Toolbox". This M/EEG toolbox is developed by researchers from the Cyclotron Research Centre, University of Li ege, Belgium, with the financial ...
Vanhaudenhuyse, A., Schnakers, C., Boly, M., Bruno, M.-A., Gosseries, O., Cologan, V., Boveroux, P., Ledoux, D., Piret, S., Phillips, C., Moonen, G., Luxen, A., Maquet, P., Brédart, S., & Laureys, S. (2007). Evaluation comportementale et par neuroimagerie fonctionnelle des patients en état végétatif. Revue Médicale de Liège, 62 Spec No, 15-20.
Peer reviewed (verified by ORBi)
Currently, there remains a high rate of misdiagnosis of the vegetative state. This should incite clinicians to use the most sensitive "coma scales" to detect signs of consciousness in these patients. The gold ...
Friston, K. J., Henson, R., Phillips, C., & Mattout, J. (2006). Bayesian estimation of evoked and induced responses. Human Brain Mapping, 27(9), 722-735.
Peer reviewed (verified by ORBi)
We describe an extension of our empirical Bayes approach to magnetoencephalography/electroencephalography (MEG/EEG) source reconstruction that covers both evoked and induced responses. The estimation scheme is ...
Albouy, G., Ruby, P., Phillips, C., Luxen, A., Peigneux, P., & Maquet, P. (2006). Implicit oculomotor sequence learning in humans: Time course of offline processing. Brain Research, 1090, 163-171.
Peer reviewed (verified by ORBi)
Studies of manual and digital sequence learning indicate that motor memories continue to be processed after training has ended, following a succession of identifiable steps. However, it is not known whether ...
Mattout, J., Phillips, C., Penny, W. D., Rugg, M. D., & Friston, K. J. (2006). MEG source localization under multiple constraints: An extended Bayesian framework. Neuroimage, 30(3), 753-767.
Peer reviewed (verified by ORBi)
To use Electroencephalography (EEG) and Magnetoencephalography (MEG) as functional brain 3D imaging techniques, identifiable distributed source models are required. The reconstruction of EEG/MEG sources rests ...
Desseilles, M., Dang Vu, T. T., Laureys, S., Peigneux, P., Degueldre, C., Phillips, C., & Maquet, P. (2006). A prominent role for amygdaloid complexes in the Variability in Heart Rate (VHR) during Rapid Eye Movement (REM) sleep relative to wakefulness. NeuroImage, 32(3), 1008-1015.
Peer reviewed (verified by ORBi)
Rapid eye movement sleep (REMS) is associated with intense neuronal activity, rapid eye movements, muscular atonia and dreaming. Another important feature in REMS is the instability in autonomic, especially in ...
Vandewalle, G., Balteau, E., Phillips, C., Degueldre, C., Moreau, V., Sterpenich, V., Albouy, G., Darsaud, A., Desseilles, M., Dang Vu, T. T., Peigneux, P., Luxen, A., Dijk, D.-J., & Maquet, P. (2006). Daytime light exposure dynamically enhances brain responses. Current Biology, 16(16), 1616-21.
Peer reviewed (verified by ORBi)
In humans, light enhances both alertness and performance during nighttime and daytime [1-4] and influences regional brain function [5]. These effects do not correspond to classical visual responses but involve ...
Phillips, C., Mattout Jeremie, Rugg, M. D., Maquet, P., & Friston, K. J. (2005). An empirical Bayesian solution to the source reconstruction problem in EEG. Neuroimage, 24(4), 997-1011.
Peer reviewed (verified by ORBi)
Distributed linear solutions of the EEG source localisation problem are used routinely. In contrast to discrete dipole equivalent models, distributed linear solutions do not assume a fixed number of active ...
Dang Vu, T. T., Desseilles, M., Laureys, S., Degueldre, C., Perrin, F., Phillips, C., Maquet, P., & Peigneux, P. (2005). Cerebral correlates of delta waves during non-REM sleep revisited. NeuroImage, 28(1), 14-21.
Peer reviewed (verified by ORBi)
We aimed at characterizing the neural correlates of delta activity during Non Rapid Eye Movement (NREM) sleep in non-sleep-deprived normal young adults, based on the statistical analysis of a positron emission ...
Peigneux, P., Laureys, S., Fuchs, S., Collette, F., Perrin, F., Reggers, J., Phillips, C., Degueldre, C., Del Fiore, G., Aerts, J., Luxen, A., & Maquet, P. (2004). Are spatial memories strengthened in the human hippocampus during slow wave sleep? Neuron, 44(3), 535-545.
Peer reviewed (verified by ORBi)
In rats, the firing sequences observed in hippocampal ensembles during spatial learning are replayed during subsequent sleep, suggesting a role for posttraining sleep periods in the offline processing of ...
Peigneux, P., Laureys, S., Fuchs, S., Destrebecqz, A., Collette, F., Delbeuck, X., Phillips, C., Aerts, J., Del Fiore, G., Degueldre, C., Luxen, A., Cleeremans, A., & Maquet, P. (2003). Learned material content and acquisition level modulate cerebral reactivation during posttraining rapid-eye-movements sleep. NeuroImage, 20(1), 125-134.
Peer reviewed (verified by ORBi)
We have previously shown that several brain areas are activated both during sequence learning at wake and during subsequent rapid-eye-movements (REM) sleep (Nat. Neurosci. 3 (2000) 831-836), suggesting that ...
Faymonville, M.-E., Roediger, L., Del Fiore, G., Delgueldre, C., Phillips, C., Lamy, M., Luxen, A., Maquet, P., & Laureys, S. (2003). Increased cerebral functional connectivity underlying the antinociceptive effects of hypnosis. Cognitive Brain Research, 17(2), 255-262.
Peer reviewed (verified by ORBi)
The neural mechanisms underlying the antinociceptive effects of hypnosis are not well understood. Using positron emission tomography (PET), we recently showed that the activity in the anterior cingulate cortex ...
Phillips, C., Rugg, M. D., & Friston, K. J. (2002). Systematic regularization of linear inverse solutions of the EEG source localization problem. NeuroImage, 17(1), 287-301.
Peer reviewed (verified by ORBi)
Distributed linear solutions of the EEG source localization problem are used routinely. Here we describe an approach based on the weighted minimum norm method that imposes constraints using anatomical and ...
Phillips, C., Rugg, M. D., & Friston, K. J. (2002). Anatomically informed basis functions for EEG source localization : Combining functional and anatomical constraints. Neuroimage, 16(3), 678-695 Part 1.
Peer reviewed (verified by ORBi)
Distributed linear solutions have frequently been used to solve the source localization problem in EEG. Here we introduce an approach based on the weighted minimum norm (WMN) method that imposes constraints ...
Friston, K. J., Glaser, D. E., Henson, R. N., Kiebel, S., Phillips, C., & Ashburner, J. (2002). Classical and Bayesian inference in neuroimaging: Applications. Neuroimage, 16(2), 484-512.
Peer reviewed (verified by ORBi)
In Friston et al. ((2002) Neuroimage 16: 465-483) we introduced empirical Bayes as a potentially useful way to estimate and make inferences about effects in hierarchical models. In this paper we present a ...
Friston, K. J., Penny, W., Phillips, C., Kiebel, S., Hinton, G., & Ashburner, J. (2002). Classical and Bayesian inference in neuroimaging : Theory. Neuroimage, 16(2), 465-483.
Peer reviewed (verified by ORBi)
This paper reviews hierarchical observation models, used in functional neuroimaging, in a Bayesian light. It emphasizes the common ground shared by classical and Bayesian methods to show that conventional ...
Laureys, S., Peigneux, P., Phillips, C., Fuchs, S., Degueldre, C., Aerts, J., Del Fiore, G., Petiau, C., Luxen, A., Van der Linden, M., Cleeremans, A., Smith, C., & Maquet, P. (2001). Experience-dependent changes in cerebral functional connectivity during human rapid eye movement sleep. Neuroscience, 105(3), 521-525.
Peer reviewed (verified by ORBi)
One function of sleep is hypothesized to be the reprocessing and consolidation of memory traces (Smith, 1995; Gais et al., 2000; McGaugh, 2000; Stickgold et al., 2000). At the cellular level, neuronal ...
Maquet, P., Laureys, S., Peigneux, P., Fuchs, S., Petiau, C., Phillips, C., Aerts, J., Del Fiore, G., Degueldre, C., Meulemans, T., Luxen, A., Franck, G., Van der Linden, M., Smith, C., & Cleeremans, A. (2000). Experience-dependent changes in cerebral activation during human REM sleep. Nature Neuroscience, 3(8), 831-836.
Peer reviewed (verified by ORBi)
The function of rapid-eye-movement (REM) sleep is stiil unknown. One prevailing hypothesis suggests that REM sleep is important in processing memory traces. Here, using positron emission tomography (PET) and ...
Laureys, S., Goldman, S., Phillips, C., van Bogaert, P., Aerts, J., Luxen, A., Franck, G., & Maquet, P. (1999). Impaired effective cortical connectivity in vegetative state : Preliminary investigation using PET. Neuroimage, 9(4), 377-382.
Peer reviewed (verified by ORBi)
Vegetative state (VS) is a condition of abolished awareness with persistence of arousal. Awareness is part of consciousness, which itself is thought to represent an emergent property of cerebral neural ...
Maquet, P., & Phillips, C. (1998). Functional brain imaging of human sleep. Journal of Sleep Research, 7(Suppl. 1), 42-47.
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This paper presents an overview of the contribution of functional brain mapping to the study of human sleep. Early studies were essentially successful in describing the variations of the global level of ...
Ashburner, J., Barnes, G., Chen, C.-C., Daunizeau, J., Flandin, G., Friston, K., Gitelman, Glauche, V., Henson, R., Hutton, C., Kiebel, S., Kilner, J., Litvak, V., Mattout, J., Moran, R., Penny, W., Phillips, C., Rosa, M., & Klaas, S. (1994). Statistical Parametric Mapping.
Statistical Parametric Mapping refers to the construction and assessment of spatially extended statistical processes used to test hypotheses about functional imaging data. These ideas have been instantiated in ...